Will paracetamol reduce the opioid requirements and the (opioid)related postoperative nausea?
- Conditions
- Paracetamol is used as a complimentary painrelief.Using sealed envelopes, 140 patients will be randomly assigned to receive either 1g paracetamol as tablets (Panodil® Glaxo Smith Kline) or 1g placebo every 6th hour after heartsurgery for 3 days. The occurrence of postoperative nausea will be assessed. Pain will be evaluated.The total amount of opioids will be noted and calculated.After the study we will break the code with sealed envelopes.MedDRA version: 9.1Level: LLTClassification code 10028818Term: Nausea postoperative
- Registration Number
- EUCTR2007-000351-33-SE
- Lead Sponsor
- Karolinska Universitetssjukhuset Solna
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- Male
- Target Recruitment
- 140
Inclusion Criteria
140 patients , undergoing heart surgery will be randomised upon arrival to the intensive care unit to receive either paracetamol every 6th hour or placebo. 18 years and older.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Patients not suited for paracetamol. Non conversationable. Women.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method