Levels of Pigment Epithelium-derived Factor in Patients With Psoriasis.
Not Applicable
- Conditions
- Psoriasis
- Interventions
- Other: serum samples and punch skin biopsies
- Registration Number
- NCT05252741
- Lead Sponsor
- Sohag University
- Brief Summary
Psoriasis is an immune-mediated chronic inflammatory skin disease associated with increase interaction of inflammatory mediators like adipokines. Pigment epithelium-derived factor (PEDF) is one of the most abundant adipokines and have anti-angiogenesis effect. There is a study showed that PEDF level is up-regulated in the sera of psoriasis patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
Patients with psoriasis and group of age and sex-matched healthy volunteers will be included as a control group.
Exclusion Criteria
- Pregnancy.
- Patients with other inflammatory skin disorders.
- Patients on antioxidants or anti-inflammatory drugs.
- Patients on topical or systemic treatment for psoriasis in the last 4 weeks prior to enrollment in the study.
- Patients on systemic retinoids (Acitretin).
- Obesity: body mass index (BMI ) > 30.
- Malignancies e.g squamous cell carcinoma.
- Viral warts.
- Diabetes.
- Hypertension.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group 2: age-, sex-, BMI-, and weight-matched control subjects. serum samples and punch skin biopsies - Group 1: patients with psoriasis serum samples and punch skin biopsies -
- Primary Outcome Measures
Name Time Method changes in serum and tissue levels of (PEDF) in patients with psoriasis 12 months evaluate serum and tissue level of (PEDF) in patients with psoriasis.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Faculty of Medicine Sohag University
🇪🇬Sohag, Egypt