Treatment of Lateral Epicondylitis. Platelet Rich Plasma vs. Steroid vs. Saline Solution
Overview
- Phase
- Not Applicable
- Intervention
- Platelet Rich Plasma
- Conditions
- Lateral Epicondylitis
- Sponsor
- University of Aarhus
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Changes in pain as a continuous outcome measure. Using The Patient-Rated Tennis Elbow Evaluation (PRTEE) questionaire.
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
We wish to address the efficacy and safety of Platelet Rich Plasma (blood platelets), a new treatment for lateral epicondylitis (tennis elbow) and compare this new treatment to either injection with steroid or saline solution.
All injections are guided by ultrasonography.
Detailed Description
Plate Rich Plasma (PRP) is a new treatment for tendinopathy. A high concentration of blood platelets is made from the patients own blod, and then injected into the tendon. The idea is that the complex mixture of growth factors within the platelets can stimulate the healing process of the tendon. We want to address the efficacy and safety of this new treatment and compare it to either the best documented treatment, Steroid injection, or to a saline solution. We want to make a randomized controlled trial with 60 participants, 20 in each of the 3 groups, and a 12 months follow up. All injections are guided by ultrasonography.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Duration of tennis elbow \> 6 months
- •Doppler activity on ultrasonography
- •Lateral elbow pain that is maximal over the lateral epicondyle, and increases with pressure on the lateral epicondyle, and resisted dorsiflexion and/or middle finger.
Exclusion Criteria
- •Inflammatory disease.
- •Fibromyalgia.
- •Pain in hand or shoulder/neck in the same arm as being treated.
- •Anticoagulation treatment.
- •Wounds around the elbow.
- •Treatment with steroids within the last 3 months.
Arms & Interventions
Platelet Rich Plasma
Intervention: Platelet Rich Plasma
Isotonoic Saline Solution
Intervention: Isotonic Saline Solutions
Steroid (Triamcinolonacetonid)
Intervention: Triamcinolonacetonid
Outcomes
Primary Outcomes
Changes in pain as a continuous outcome measure. Using The Patient-Rated Tennis Elbow Evaluation (PRTEE) questionaire.
Time Frame: first day, 1 months, 3 months, 6 months, 12 months.
We use the PRTEE questionaire, which is validated for tennis elbow.
Secondary Outcomes
- Functional Disability(First day, 1 month, 3 months, 6 months, 12 months)
- Ultrasonographic changes(first day, 1 months, 3 months, 6 months, 12 months)
- Adverse events(through out the entire 12 months)
- Pain induced by the treatment(1 months after treatment)