Metabolic Responses of a Single Bout of Low-intensity Exercise Following Mixed Meals in Healthy Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 主要终点
- Plasma glucose responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
研究概览
简要总结
In the present study the investigators compared the hormonal and metabolic effects of three meal loads very popular among Italian eating habits, both in the resting- and exercising state. Given the lack of time is considered a common barrier to exercise adherence, we wanted to identify a low dose of exercise capable to produce health benefits in the post-absorptive status elicited by three commonly consumed meal-models in Mediterranean countries. To this end, healthy young volunteers firstly underwent an oral glucose tolerance test (OGTT) and three meal tolerance tests. Secondly, in an extra set of experiments, subjects cycled at low intensity for the last 20 minutes of the same glucose/meal tolerance test. Glycemia, insulinemia, ghrelinemia, lipidemia, and satiety were measured throughout OGTT and each test-meal load.
详细描述
The investigators evaluated postprandial responses (glucose, insulin, ghrelin, free fatty acids (FFA)) elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise were investigated. All subjects underwent a 50-g OGTT (A) and 3 test-meal loads: milk and cereals (B1); milk, apple and chocolate cream-filled sponge cake (B2); milk, bread, apple and hazelnut chocolate cream (B3). In the exercise trial, participants cycled for 20 minutes at 40% VO2max, 100 minutes after load ingestion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age between 18 and 40 years
- •normal body weight (BMI =18.5 - 24.9 according to NHLBI)
- •stable diet
排除标准
- •Diabetes, tipe 1 and 2 (ADA criteria)
- •Glucose intolerance (ADA criteria)
- •Dyslipidemia (ATP III according to NCEP)
- •Metabolic syndrome
研究组 & 干预措施
Breakfast without exercise
Each subject of the same arm underwent 2 interventions: breakfast with/without exercise
干预措施: Breakfast (Dietary Supplement)
Breakfast with exercise
Each subject of the same arm underwent 2 interventions: breakfast with/without exercise
干预措施: exercise (Other)
Breakfast with exercise
Each subject of the same arm underwent 2 interventions: breakfast with/without exercise
干预措施: Breakfast (Dietary Supplement)
结局指标
主要结局
Plasma glucose responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
时间窗: The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Postprandial glycemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.
Plasma insulin responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
时间窗: The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Postprandial insulinemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.
Plasma ghrelin responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
时间窗: The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Postprandial ghrelinemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.
Plasma free fatty acids (FFA) responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
时间窗: The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Postprandial plasma FFA responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.
次要结局
未报告次要终点
研究者
Livio Luzi
M.D., Full Professor of Endocrinology
Ospedale San Donato