Metabolic Responses of a Single Bout of Low-intensity Exercise Following Mixed Meals in Healthy Individuals
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Metabolism and Nutrition Disorder
- Sponsor
- Ospedale San Donato
- Enrollment
- 19
- Primary Endpoint
- Plasma glucose responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
In the present study the investigators compared the hormonal and metabolic effects of three meal loads very popular among Italian eating habits, both in the resting- and exercising state. Given the lack of time is considered a common barrier to exercise adherence, we wanted to identify a low dose of exercise capable to produce health benefits in the post-absorptive status elicited by three commonly consumed meal-models in Mediterranean countries. To this end, healthy young volunteers firstly underwent an oral glucose tolerance test (OGTT) and three meal tolerance tests. Secondly, in an extra set of experiments, subjects cycled at low intensity for the last 20 minutes of the same glucose/meal tolerance test. Glycemia, insulinemia, ghrelinemia, lipidemia, and satiety were measured throughout OGTT and each test-meal load.
Detailed Description
The investigators evaluated postprandial responses (glucose, insulin, ghrelin, free fatty acids (FFA)) elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise were investigated. All subjects underwent a 50-g OGTT (A) and 3 test-meal loads: milk and cereals (B1); milk, apple and chocolate cream-filled sponge cake (B2); milk, bread, apple and hazelnut chocolate cream (B3). In the exercise trial, participants cycled for 20 minutes at 40% VO2max, 100 minutes after load ingestion.
Investigators
Livio Luzi
M.D., Full Professor of Endocrinology
Ospedale San Donato
Eligibility Criteria
Inclusion Criteria
- •age between 18 and 40 years
- •normal body weight (BMI =18.5 - 24.9 according to NHLBI)
- •stable diet
Exclusion Criteria
- •Diabetes, tipe 1 and 2 (ADA criteria)
- •Glucose intolerance (ADA criteria)
- •Dyslipidemia (ATP III according to NCEP)
- •Metabolic syndrome
Outcomes
Primary Outcomes
Plasma glucose responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
Time Frame: The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Postprandial glycemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.
Plasma insulin responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
Time Frame: The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Postprandial insulinemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.
Plasma ghrelin responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
Time Frame: The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Postprandial ghrelinemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.
Plasma free fatty acids (FFA) responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.
Time Frame: The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Postprandial plasma FFA responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.