ISRCTN56652283已完成2 期
Randomized phase II Trial of combined chemoradiation with Epidermal Growth Factor Receptor (EGFR) antagonist Cetuximab versus combined chemoradiation with EGFR antagonist Cetuximab and sequential Cetuximab for patients with locally advanced pancreatic adenocarcinoma
niversity of Heidelberg (Germany)0 个研究点目标入组 66 人开始时间: 2005年6月13日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 66
研究概览
简要总结
Study protocol in http://www.ncbi.nlm.nih.gov/pubmed/16219105
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Patients with locally advanced primary inoperable pancreatic cancer
排除标准
- •1. Active infection
- •2. Liver function impairment
- •3. Pregnancy
- •4. Breast feeding
- •5. Metastatic disease
- •6. Elevated serum calcium level
- •7. Other severe systemic disease
- •8. Second malignancy (except carcinoma in situ of the cervix uteri, basal cell carcinoma of the skin after adequate oncologic treatment)
- •9. Any other experimental treatment four weeks before study inclusion
- •10. Known positive HACA (Human Anti-Chimeric Antibody)
- •11. Known allergy against extrinsical proteins
- •12. Previous antibody therapy
- •13. Allergy against intravenous (iv) contrast agent (for Computed Tomography [CT]-scans)
- •14. Previous chemo- and/or radiation treatment or EGFR-inhibitor therapy for pancreatic cancer
研究者
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