Assessment of Ventilation-perfusion Abnormalities in Patients With Smoking-related Airways Disease in Stable Condition and the Effect of Bronchodilator Therapy
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- scan grade
研究概览
简要总结
Subjects undergo history, examination, lung function assessment after informed consent has been obtained. All subjects will undergo ventilation-perfusion scans. If there first scan is normal they will undergo a second and final scan four weeks later. If abnormal they will undergo two further scans with either nebulized bronchodilator or nebulized saline prior to their second and third scans. Each time they will have repeat lung function tests prior to scanning. We will examine the regional changes in ventilation and perfusion and there relationship to lung function.
详细描述
As in Brief description
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •FEV1 < 70% predicted at baseline on spirometry
- •significant smoking history or alpha 1 antitrypsin deficiency
- •no evidence of current infection or restrictive lung disease
排除标准
- •history of other significant respiratory disease
- •significant respiratory infection within 6 weeks
- •history of significant physical or mental illness rendering them unfit for the study in the opinion of the investigator
- •taken part in any other research within the past 12 months, or received exposure to ionizing radiation
研究组 & 干预措施
saline control
nebulized saline
干预措施: nebulized saline (Drug)
salbutamol and ipratropium bromide nebules
salbutamol 2.5 mg and ipratropium bromide 0.5 mg
干预措施: salbutamol + ipratropium bromide nebules (Drug)
结局指标
主要结局
scan grade
时间窗: post scan
previously validated grading score
次要结局
- lung function(pre scan)
研究者
Philip Ind
Consultant Physician
Imperial College London