Association Between Elevated Plasma D-dimer in Adult Community-acquired Pneumonia Patients and Severity of Inflammatory Response and Survival
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- find the correlation between plasma D-dimer level and the severity of CAP
研究概览
简要总结
This observational study aims to investigate the association between elevated plasma D-dimer levels and the inflammatory response, as well as its impact on survival in adult patients with community-acquired pneumonia.
the study participants will be subjected to sampling for D-dimer and calculation of CURB-65 score. this aims to find the relation between them
详细描述
Community-acquired pneumonia (CAP) is a common and potentially life-threatening infection that affects millions of individuals worldwide each year.
D-dimer is a fibrin degradation product that is elevated in many conditions associated with inflammation and coagulation activation, including pneumonia.
This is an observational study including a minimum of 50 patients with CAP
Patients who will be admitted to the Chest department, or coming to the outpatient clinic at Ain-Shams University Hospitals with CAP, and have the following inclusions:
- age ≥18 years
- diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.
- Did not have any clinical or radiological signs suggesting COVID-19 pneumonia Exclusion criteria Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who will be admitted to the Chest department, or coming to the outpatient clinic at Ain-Shams University Hospitals with CAP, and have the following inclusions:
- •age ≥18 years
- •diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.
排除标准
- •Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
- •patients who have any clinical or radiological signs suggesting COVID-19 pneumonia.
研究组 & 干预措施
only one group which will include patients with CAP to take a blood sample for D-dimer
干预措施: Blood Product (Other)
结局指标
主要结局
find the correlation between plasma D-dimer level and the severity of CAP
时间窗: in 6 months
measuring D-dimer level (\< 500 µg/L consider negative) on admission and correlating this with CAP severity.
次要结局
未报告次要终点
研究者
hieba gamal ezz-elragal awad
Assistant professor
Ain Shams University