Molecular and Cellular Mechanisms of the In-stent-thrombosis
Withdrawn
- Conditions
- Patients With SAT or LT After Stent Implantation (PCI)
- Registration Number
- NCT00652015
- Lead Sponsor
- RWTH Aachen University
- Brief Summary
In-Stent-Thrombosis is a rare but serious complication after implantation of stents during PTCA.
- Detailed Description
In this prospective, open, not-randomized, controlled single-center pilot study 80 patients having had an in-stent-thrombosis (40 sub-acute thromboses (SAT), 40 late thromboses (LT)) and a control group of 80 patients having not developed a thrombosis will be compared.
The aim of this study is the establishment of diagnostic markers vor prediction of SAT (detection of CD39- and CD73-activity, respectively)and of LT (EPC-number and function, respectively) correspondingly aiming at the early identification of patients with high risk for developing an in-stent-thrombosis.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- patients having developed an SAT or LT after stent implantation using PTCA
Exclusion Criteria
- instabel coronary heart diseases,
- systemic autoimmune diseases,
- rheumatic diseases,
- tumors,
- impaired kidney or liver function,
- surgery within the last 3 months,
- pregnant or lactating women
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The aim of this study is to establish diagnostic markers for prediction of SAT and LT, respectively, by identification of CD39 and CD73-activity and EPC-number and function, respectively. may 08 to may 2010
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
RWTH University Hospital
🇩🇪Aachen, Germany
RWTH University Hospital🇩🇪Aachen, Germany