the evaluation of Clonidine versus Ondansetron for control of pain, nausea & vomiting after Orthognathic surgery.

Phase 3

• Conditions: Condition 1: pain after orthosurgery. Condition 2: nausea and vomiting after orthosurgery. Condition 3: Jaw deformity.; Pain in joint; Vomiting associated with other psychological disturbances; Dentofacial anomaly, unspecified

• Registration Number: IRCT2017012922697N2
• Lead Sponsor: Vice chancellor for research Mashhad university of medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

All adult patients with ASA class I, II, age range between 18 and 40 years and BMI less than 30 kg per square meter, with jaw deformity and applicable for orthosurgery that referred to Mashhad dental school.

Exclusion criteria:
Patients with ASA III class and more.
Patients with history of nausea in moving vehicles (Motion sickness)
Patients who had experience of previous Ponv, nausea and vomiting in last 24 hours
Patients with upper gastrointestinal disorders such as peptic ulcer disease, re flux, pyloric stenosis
Patients with history of drug abuse and addiction
Patients known to be sensitive to clonidine and ondansetron
Patients with history of low blood pressure and bradycardia
Patients who need to be care in ICU after surgery.
Patients who not wish to continue participation in the program, for any reason.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Amount of pain. Timepoint: 1,3,6,12,24 hours after surgery. Method of measurement: VAS.;Nausea and vomiting amount after surgery. Timepoint: 1,3,6,12,24 hours after surgery. Method of measurement: yes or no / dose of rescue anti emetic drug.

Secondary Outcome Measures

Name	Time	Method
Bradycardia. Timepoint: 1,3,6,12,24 hours after surgery. Method of measurement: clinical observation.;Blood pressure. Timepoint: 1,3,6,12,24 hours after surgery. Method of measurement: clinical observation.