EUCTR2010-020698-17-BE
Active, not recruiting
Not Applicable
Study of the vascular wall with functional imaging in OSA patients.
Antwerp University Hospital : Department Respiratory Medicine0 sitesOctober 7, 2010
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obstructive sleep apnea (OSA) is a prevalent disorder and characterised by sleepiness during the daytime, fatigue and impairments of concentration. OSA can also lead to cardiovascular pathology due to an increase of sympathetic activity and possibly also by complex inflammatory processes and oxidative stress at the vascular wall due to intermittent hypoxemia. It is particularly important to modulate and describe the structure of the vascular wall in this population.
- Sponsor
- Antwerp University Hospital : Department Respiratory Medicine
- Status
- Active, not recruiting
- Last Updated
- 11 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. male or female \>25 years
- •2\. OSA patients with AHI\>20
- •3\. Eligible for CPAP therapy according to the Belgian OSA convention
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range
- •F.1\.3 Elderly (\>\=65 years) no
- •F.1\.3\.1 Number of subjects for this age range
Exclusion Criteria
- •1\. patients who cannot delay CPAP therapy
- •2\. excessive disturbing sleepiness in opinion of the doctor who advises immediate treatment
- •3\. pregnancy/lactation or becoming pregnant during the study period
- •4\. common cold the last 2W before the start of the study
- •5\. significant GI, liver, cardiovascular, neurological, renal or hematologic disease, uncontrolled with the current treatment
- •6\. use of ICS, nasal and oral corticosteroids, NAC, statins, antibiotic use 8 weeks before the start of the study
- •7\. patients with dislipidemia (totaal CH \> 240 mg/dl, LDL \> 160, HDL\<35, TG\>200\)
- •8\. use of vitamines
- •9\. coronary artery disease
- •10\. diabetes mellitus
Outcomes
Primary Outcomes
Not specified
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