Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment
- Conditions
- Depressive Disorder, Treatment-Resistant
- Registration Number
- NCT04956016
- Lead Sponsor
- Centre Hospitalier Henri Laborit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 152
Inclusion Criteria:<br><br> - Volunteer subjects over 18 years old<br><br> - Having signed a free and informed consent<br><br> - Having a diagnostic of caracterised depressive episod recurrent or isolated<br> according to DSM IV criteria (A.P.A 1994).<br><br> - Having an antidepressant treatment not modified since 3 weeks<br><br> - Score to MADRS scale = 21<br><br> - Subject affiliated to a social security regimen<br><br>Exclusion Criteria:<br><br> - Depression with psychotic caracteristics<br><br> - Co-morbid diagnosis according to axis I (DSM IV) of schizophrenia, dependence (or<br> abuse) on alcohol and / or another substance (lifetime)<br><br> - Patient who has already undergone seismotherapy for current episode and<br> non-responder to this treatment<br><br> - Patient hospitalized under duress or under legal protection (guardianship,<br> curatorship)<br><br> - Patient with a high risk of suicide (item 10 of MADRS > 4) in the absence of<br> hospitalization.<br><br> - Contra-indication for IRM exam or rTMS : personnal history of comitial crisis, of<br> neurological or neurochirurgical pathologies, metallic prosthetic material or<br> foreign body (pacemaker, intraoculare ferromagnetic material, implanted cardiac<br> defibrillator, cochlear implant, metal clip<br><br> - Pregnancy<br><br> - Simultaneous participation to another interventionnal study
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A 50% change of MADRS score
- Secondary Outcome Measures
Name Time Method