Effect of Preoperative Oral Carbohydrates on the Glycemic Variability of Diabetic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Glycemic variability
研究概览
简要总结
Preoperative carbohydrate drink intake attenuate insulin resistance. However, carbohydrate loading may compromise blood glucose control in patients with diabetes. There is some evidence that oral carbohydrate loading may be safe in patients with type 2 diabetes. Therefore, the investigators aim to evaluate whether preoperative carbohydrate intake affects insulin resistance and glycemic variability in patients with diabetes. Fifty patients scheduled for total knee arthroplasty will be divided into carbohydrate (n=25) and control (n=25) groups. Randomly selected patients of the carbohydrate group are given 400ml of 12.8 g/100 ml carbohydrate beverage 2-3 hours before their scheduled operation. In contrast, patients in the control group are fasted from water 2 hours before surgery according to standard protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing total knee arthroplasty
排除标准
- •Patients with contraindications to spinal anesthesia (local infection, clotting disorders, anatomical abnormalities, sepsis, etc.)
- •Patients with gastroesophageal reflux disease, gastric emptying disorders, inflammatory bowel disease, or previous treatment for intra-abdominal cancer
- •Patients with chronic renal disease or severe cardiovascular disease
- •HbA1c >69 mmol/mol or BMI >30 kg/m2
- •A duration of ≥5 hours between consumption of CHO and initiation of surgery.
- •The subject is a foreigner or illiterate
结局指标
主要结局
Glycemic variability
时间窗: 1 hour after surgery
- Coefficient of glucose variability =SD/mean x 100 (%)
次要结局
- gastric volume(Before anesthesia)
- hand grip strength(Before anesthesia)
- Insulin resistance(Before anesthesia)