The Effect of Tyrosine Kinase Receptor Axl on Dialysis Prognosis in Chronic Hemodialysis Patients: a Cohort Study
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 250
- Locations
- 1
- Primary Endpoint
- death
Study Overview
Brief Summary
The purpose of this study is to evaluate whether tyrosine kinase receptor Axl affects the dialysis prognosis in chronic hemodialysis patients
Detailed Description
It is reported that hemodialysis (HD) patients often develop chronic systemic inflammatoion, and increased inflammatory activity is associated with vascular access failure, cardiovascular disease and death in HD patients. The interaction of Axl and its ligand Gas6 plays an important role in modulating immune response, inhabiting toll-like receptor (TLR) signaling and suppressing inflammatory cytokines production. Thus, we want to investigate the relationship between tyrosine kinase receptor Axl and the dialysis prognosis in HD patients in three-years follow-up.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •hemodialysis for more than 6 months
Exclusion Criteria
- •patients who received warfarin therapy;
- •patients with chronic infectious disease or acute infection;
- •patients with hemodialysis inadequacy;
- •the age of patients is older than 65 years or younger than 18 years.
- •patients who can not sign an informed consent or disagree to follow up
Outcomes
Primary Outcomes
death
Time Frame: 3 years
death
dialysis complication
Time Frame: 3 years
vascular access failure, stroke, acute coronary syndrome, heart failure
Secondary Outcomes
No secondary outcomes reported
Investigators
Ai Peng
Director of the department of Nephrology,Shanghai 10th people's hospital
Shanghai 10th People's Hospital