Beneficial Exposome: Investigating Its Effect on Human Health
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Resting Heart Rate
研究概览
简要总结
The purpose of this study is to explore the positive, holistic health outcomes resulting from regular exposure to naturally occurring compounds predicted to have health benefits. The researchers hope to learn how the human body is influenced by regular exposure to these compounds.
详细描述
Considerable research has been conducted on the effects of environmental exposure on human diseases. This is also known as "exposome" research. However, there is limited research on the impact of beneficial exposomes found in the natural environment. The researchers would like to identify and measure the benefits of these naturally occurring compounds on holistic human health.
Through blood specimens, the researchers will observe biomarkers such as cortisol levels and inflammatory markers. Data will be collected from wearable sensors to observe the effects of beneficial exposomes on areas such as cardiovascular health and sleep quality. There will be surveys to understand well-being, stress, and mood. Through such observations, this study aims to understand the positive impacts of intentional exposure to selected compounds found in nature.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years of age and older
- •Read, speak, and understand English
- •Live in the US territory
排除标准
- •Mental incapacity and/or cognitive impairment on the part of the patient that would preclude adequate understanding of, or cooperation with, the study protocol
- •Is pregnant
- •Is breastfeeding
- •Has epilepsy
- •Has allergies to Cupressaceae family of plants, common plants include redwoods, junipers, cypress, cedar, fir, and sequoia
结局指标
主要结局
Resting Heart Rate
时间窗: Baseline; 26 weeks
Change in resting heart rate measured by wearable devices
Heart Rate Variability
时间窗: Baseline; 26 weeks
Change in resting heart rate measured by wearable devices
Change in sleep quality measured as duration of sleep stages
时间窗: Baseline; 26 weeks
Duration of each sleep stage \[i.e. light, deep, rapid eye movement (REM), wake stages\] overnight. Sleep quality will be measured via a wearable device. Sleep quality will be compared to baseline through the other intervention phases.
Profile of Mood States
时间窗: Baseline; weeks 2, 6, 10, 14, 18, 22, and 26
Change in mood states, a 65 item scale that allow for the quick assessment of transient, fluctuating feelings and enduring affect states.
次要结局
- Metabolome(Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26)
- Proteome(Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26)
- Transcriptome(Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26)
- Well-being(Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26)
- Perceived Stress(Baseline; weeks 2, 6, 10, 14, 18, 22, and 26)
- Generalized Anxiety(Baseline; weeks 2, 6, 10, 14, 18, 22, and 26)
- Depression(Baseline; weeks 2, 6, 10, 14, 18, 22, and 26)
- Inflammation Profile(Baseline; weeks 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26)
研究者
Michael Snyder
Professor of Genetics & Genetics Department Chair
Stanford University