An Exercise Intervention to Improve Overall Brain Health

Not Applicable

Recruiting

• Conditions: Brain Care Score; Exercise; Hypertension; BMI
• Interventions: Behavioral: Exercise Intervention to improve overall Brain Health

• Registration Number: NCT06035094
• Lead Sponsor: University of Alabama at Birmingham

Brief Summary

The goal of this clinical trial is to test the effects of 10 weeks of exercise on overall brain health, reduction in blood pressure, and the number of blood vessels in the back of the eyes in patients with hypertension and have a body mass index ≥ 25 kg/m2. The main question\[s\] it aims to answer are:

* To test the effect of moderate vs intensive exercise on Brain Care Score outcomes.

* To ascertain the differential impact of moderate vs high intensity exercise in reducing hypertension and its downstream effects.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-09-06
• Study First Submitted QC: 2023-09-06
• Study First Posted: 2023-09-13
• Study Start: 2024-01-23
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-26
• Last Update Posted: 2024-06-28
• Primary Completion: 2025-06
• Study Completion: 2026-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• diagnosed with hypertension
• have a body mass index ≥ 25 kg/m2
• are between the ages of 35-65 years old
• access to a smart phone that allows installation of 2 two applications that record your workouts
• pass a fitness evaluation.

Exclusion Criteria

• do not have hypertension
• weight over 300 lbs
• unable to pass the fitness evaluation
• BMI less than 25kg/m2

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High Intensity Interval Training (HIIT) exercise group,	Exercise Intervention to improve overall Brain Health	Participants will be asked to exercise independently 4 days/week for 10 weeks, following a high intensity interval training (HIIT) protocol.
Control exercise group	Exercise Intervention to improve overall Brain Health	Participants will be advised to follow the American Heart Association (AHA) guidelines on exercise.
Moderate Intensity Training (MIT) exercise group	Exercise Intervention to improve overall Brain Health	Participants will be asked to exercise independently 4 days/week for 10 weeks, following a moderate intensity training (MIT) protocol.

Primary Outcome Measures

Name	Time	Method
Improved overall Brain Care Score metric.	10 weeks	The score is based on lifestyle categories on a scale of 0-21 where 21 is best.

Trial Locations

Locations (1)

UAB; 🇺🇸 Birmingham, Alabama, United States