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临床试验/NCT07055555
NCT07055555Enrolling By Invitation不适用

Disrupted Connections: The Impact of Acute Stress on Memory Integration

Nevada State University1 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2026年3月26日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
Enrolling By Invitation
发起方
入组人数
80
试验地点
1
主要终点
Performance on A-C inference trials in the Paired Associative Inference Task

研究概览

简要总结

The goal of this study is to better understand how stress impacts people's ability to learn across their experiences and link new information to what they already know. The investigators will compare performance on a memory task between stressed and non-stressed participants. This memory task requires people to integrate knowledge across learning experiences (think: having to "connect the dots", draw inferences, and generalize your knowledge to new situations and scenarios). Cortisol, the brain's primary stress hormone, will be measured at multiple points throughout the study to measure stress levels. The investigators hypothesize that:

  1. Stress will disrupt performance on the memory task by interfering with memory processes that enable linking of related memories.
  2. Higher cortisol levels, which reflect a greater stress response, will relate to greater deficits in memory performance across participants.

This research has broad implications for understanding how stress impacts the ability to learn and retain new information, particularly in high-stress environments like schools and workplaces. Additionally, this work may provide insights into the cognitive difficulties experienced by individuals with psychiatric disorders, where stress can worsen memory and learning challenges.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •healthy adults
  • •aged 18-35 years
  • •speak fluent English
  • •have normal or corrected-to-normal vision

排除标准

  • •individuals who are pregnant
  • •exercise within 1 hour of the study session
  • •smoking within 1 hour of the study session
  • •consuming drugs or alcohol within 1 hour of the study session

研究组 & 干预措施

Non-Stress Control Condition

Sham Comparator

Participants randomized to the non-stress control condition will complete a non-stressful task designed to parallel the structure of the Trier Social Stress Test without eliciting acute stress.

干预措施: Non-Stress Control Task (Behavioral)

Acute Stress Condition

Experimental

Participants randomized to the acute stress condition will complete the Trier Social Stress Test (TSST), a validated experimental method for inducing acute psychosocial stress. This condition will allow for us to evaluate our primary hypothesis.

干预措施: Acute Stress (Behavioral)

结局指标

主要结局

Performance on A-C inference trials in the Paired Associative Inference Task

时间窗: During the participant's study visit, anticipated 1-2 hours

Performance on A-C inference trials of the memory task assesses memory integration across overlapping learning experiences.

次要结局

  • Performance on directly learned pairs (A-B and B-C) in the Paired Associative Inference Task(During the participant's study visit, anticipated 1-2 hours)

研究者

发起方
Nevada State University
申办方类型
Other
责任方
Sponsor

研究点 (1)

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