Sex Difference of Coronary Microvascular Dysfunction in Patients with Non-obstructive Coronary Artery Disease

Recruiting

• Conditions: Microvascular Angina

• Registration Number: NCT06076551
• Lead Sponsor: Korea University Anam Hospital

Brief Summary

Sex difference of coronary microvascular dysfunction evaluated by coronary flow reserve will be assessed in patients with non-obstructive coronary artery disease

Detailed Description

The investigators will select consecutive patients who experienced chest pain but had no significant coronary artery stenosis (\<50% stenosis). Coronary microvascular function will be evaluated by adenosine stress echocardiography. Coronary blood flow velocities will be measured at 1, 2, and 3 min after adenosine infusion.

Sex difference of coronary microvascular dysfunction evaluated by coronary flow reserve will be assessed.

Study Timeline

• Study Start: 2018-02-01
• Study First Submitted: 2023-09-25
• Study First Submitted QC: 2023-10-06
• Study First Posted: 2023-10-11
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-24
• Last Update Posted: 2025-03-26
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Typical/atypical chest pain or ischemic symptoms including dyspnea
• No significant coronary artery stenosis (<50% stenosis) in coronary angiography or computed tomography

Exclusion Criteria

• ≥ Moderate valvular heart disease
• Congenital heart disease
• Chronic renal failure (estimated glomerular filtration rate <30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
• Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
• Receiving anticancer drugs
• Vasculitis associated with autoimmune diseases
• Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A composite outcome including all-cause mortality, nonfatal myocardial infarction, nonfatal stroke, and hospitalization for heart failure	1 year	Number of participants with a composite outcome including all-cause mortality, nonfatal myocardial infarction, nonfatal stroke, and hospitalization for heart failure

Trial Locations

Locations (1)

Korea University Anam Hospital; 🇰🇷 Seoul, Korea, Republic of