A Study Designed to Develop in Vitro Models of Liver, Biliary and Pancreatic Cancer for the Investigation of Tumour Biology and Potential Therapies
试验速览
- 阶段
- 不适用
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Number of tumour-derived organoids successfully cultured in vitro for a minimum of 3 months.
研究概览
简要总结
The primary objective is to develop an in vitro model of cancer for laboratory study using liver, biliary and pancreatic cancer tissue. The secondary objective is to study the genetic and cellular biology of cancer of the liver, biliary tract and the pancreas. As well the investigators hope to compare molecular and cellular biology of cancer cells with normal cells as well as potentially test the efficacy of current and future anti-cancer therapies.
Samples will be collected from tissue that has been resected as part of the treatment for a patient diagnosed with liver, bile duct or pancreas cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All adult patients undergoing surgical resections for liver, biliary or pancreas cancers that are able to give informed consent.
排除标准
- •Patients aged <18 or those who are unable to give informed consent.
结局指标
主要结局
Number of tumour-derived organoids successfully cultured in vitro for a minimum of 3 months.
时间窗: 3 years
次要结局
- Proportion of tumour-derived organoids that are genetically identical to the source tumour.(3 years)
研究者
Dr. Kourosh Saeb-Parsy
University Lecturer and Consulatan Transplant Surgeon
Cambridge University Hospitals NHS Foundation Trust