IRCT2015092924271N1
Completed
未知
Effects of probiotic and prebiotic supplements on serum inflamatory factors, tryptophan, cortisol, leptin and appetite in patients with major depressive disorder
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Condition 1: major depressive disoreders. Condition 2: Mild depression. Condition 3: Moderate depression.
- Sponsor
- Tehran University of Medical Sciences
- Enrollment
- 90
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •range for ages 18 to 50 years; mild to moderate melancholic type of major depression; intake of the following anti\-depressant drugs: sertraline, fluoxetine and citalopram.
- •Exclusion criteria: history of renal, hepatic, cardiovascular, respiratory diseases or food allergy; pregnancy and lactation; regular intake of probiotic less than 2 months before the beginning of the study; intake of the antioxidant or omega 3 supplements 6 weeks before the beginning of the study; alcohol intake; smoking cigarette (more than 5 Sticks during last 6 month) or tobacco (pipe and hookah at least one time during last month); any addiction to opiates; history of heart attack or stroke; following of specific diet; participation in another study during last two months; intake of drugs other than antidepressant drugs; allergy to the components of study supplements; any significant change in the diet and life style; any change in the drug regiment; inflammatory disease which last more than one week during the study; intake of antibiotics during the study.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Not specified
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