Olanzapine in the Treatment of Hair Pulling (Trichotillomania)
Phase 4
Completed
- Conditions
- Trichotillomania
- Registration Number
- NCT00182507
- Lead Sponsor
- Hamilton Health Sciences Corporation
- Brief Summary
Trichotillomania (TTM) or hair-pulling has been considered as part of the obsessive compulsive disorder (OCD) spectrum, although treatment with OCD medications has largely been unsuccessful. Tics/Tourrettes' Syndrome (TS) is a disorder, which appears to be related to TTM, but is treated with a different class of medications than used in OCD, namely antipsychotics such as olanzapine. This is a study of the safety and efficacy of olanzapine in the treatment of hair pulling.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 34
Inclusion Criteria
- primary DSM-IV trichotillomania; CGI-Severity ≥ 4
Exclusion Criteria
- Any other Axis I primary diagnosis; CGI-S < 4; current comorbid: OCD, MDD, alcohol or substance abuse; lifetime hx of: schizophrenia, bipolar affective disorder or dementia; current pregnancy/lactation; current suicidality or homicidality; major medical problems or clinically unstable medical disease; hx of: seizures, stroke or head trauma; prior use of neuroleptics
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Clinical Global Impression (CGI)-Improvement Scale ≤ 2
- Secondary Outcome Measures
Name Time Method CGI-Severity Scale, Mean change from baseline in: Yale-Brown Obsessive Compulsive Scale for TTM, the Massachusetts General Hospital Hair Pulling Scale
Trial Locations
- Locations (1)
Hamilton Health Sciences, McMaster University Medical Centre
🇨🇦Hamilton, Ontario, Canada