ACTRN12605000208606
Completed
Phase 4
A two year double blind, randomised, controlled trial to evaluate the efficacy of zoledronic acid in the prevention of bone loss in patients infected with human immunodeficiency virus taking highly active antiretroviral therapy (HAART)
Associate Professor A Grey0 sites70 target enrollmentAugust 25, 2005
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- HIV-related osteopenia
- Sponsor
- Associate Professor A Grey
- Enrollment
- 70
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •HIV positive and have taken HAART for at least 3 months and have a bone mineral density T score of less than \-0\.5SD at any site.
Exclusion Criteria
- •Renal impairment (serum creatinine \>0\.15 mmol/L), untreated hypothyroidism or hyperthyroidism, chronic liver disease, concurrent major systemic illness, including malignancy, active major gastrointestinal disease, metabolic bone diseases, primary hyperparathyroidism, more than 2 hospital admissions within 6 months of study entry, use of oral glucocorticoid drugs equivalent to an average dose of prednisone 2\.5 mg/day in the preceding six months.
Outcomes
Primary Outcomes
Not specified
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