To assess and compare the efficacy of injectable platelet-rich fibrin and microneedling in treatment of thin gingival biotype – A randomized controlled trial
试验速览
- 阶段
- 1/2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Gingival thickness
研究概览
简要总结
Gingival biotype has a role in various periodontal disease progression and outcome of several periodontal sugeries as well. Microneedling induces response similar to tissue trauma, where body’s own collagen production is induced as a result of which production of growth factors is increased which leads to proliferation of new cells and fibroblasts transforming into collagen and elastin fibres from day 5 up to week 8. Fibroblasts also trigger neoangiogenesis and neocollagenesis which may show additive effect with injectable PRF on thin gingival biotype. Therefore, the current study aims to evaluate the effectiveness of injectable platelet-rich fibrin alone and along with microneedling technique on thin gingival biotype.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients having thin gingival biotype that is less than 1mm in maxillary anterior region.
- •those should have plaque index score 0 or
- •those without any other dental abnormality in maxillary anterior region.
排除标准
- •Patients undergoing active orthodontic treatment Patients with history of periodontal surgery Patients with history of any systemic diseases Patients on blood thinners Patients using any drugs that might lead to gingival enlargement.
结局指标
主要结局
Gingival thickness
时间窗: baseline, 1 month, 3 months
次要结局
- keratinized tissue width(baseline, 1 month, 3 months)
研究者
MANSI TAKALKAR
KAHERS KLE VK Institute of dental sciences