Effect of RECOGNeyes Training on Brain Networks
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Change in strength of alpha-beta oscillatory coupling
研究概览
简要总结
RECOGNeyes is a computer game developed by members of the research team to improve attention in people who find it hard to "keep their eyes on the task". Players use a small eyetracker to control the game with their eyes, giving their gaze-control system (oculomotor control system) a thorough work-out.
This is a "confidence-in-concept" study to see whether RECOGNeyes holds promise as an approach to improving attentional control. It takes the form of a clinical trial, in which three groups of participants will undertake different amounts of RECOGNeyes training.
The goals of the study are to find out:
- Whether RECOGNeyes training changes patterns of brain activity during a challenging gaze-control task.
- What changes in brain activity participants show when their gaze control improves.
Before and after RECOGNeyes training, participants will have two kinds of brain scan:
- Magnetoencephalography to measure their brain waves while they do a gaze-control task that involves shifting their gaze to look either towards, or away from, an object that suddenly appears on the left or right side of a screen. It takes extra control to look away from the object as they have to actively resist the strong impulse to look towards it.
- Functional magnetic resonance imaging of the brain while the participants are at rest in the scanner, with their eyes open. This reveals the connection patterns between different parts of the brain when the participant is not doing anything in particular.
Participants will be healthy young adults, and recruitment will focus on young people who are receiving academic support for their studies, as they are more likely to have problems with "keeping their eyes on the task".
They will be given sealed written instructions to play RECOGNeyes at home two, three or four times per week for two weeks, playing for 20 to 30 minutes at a time. How many times per week they are to play will be decided by random draw.
From the scanning data, the researchers will:
- Measure changes in brain waves and brain connectivity before and after training.
- Measure improvements in the gaze-control task and how strongly the improvements relate to brain changes.
- See whether the brain changes relate to how long the participants spent training.
If participants who trained for longer show more improved gaze control, as well as greater brain changes, this will provide grounds for confidence in the RECOGNeyes approach to improving inattention.
详细描述
STUDY PURPOSE
RECOGNeyes is an eyetracker-controlled training game the researchers have developed in collaboration with young people with Attention Deficit/Hyperactivity Disorder (ADHD), their parents, and their teachers. It is designed to improve cognitive control in these conditions by training greater inhibitory top-down control over direction of gaze. The goal of this study is to establish whether there are grounds for confidence in the concept of gaze-control training as an approach to improving attentional control in conditions such as ADHD. The researchers will do this by investigating neural correlates of oculomotor control before and after RECOGNeyes gaze-control training, and evaluating the extent to which changes in these neural correlates themselves are associated with improved oculomotor control and with time spent training.
The researchers will use magnetoencephalography (MEG) recorded while participants undertake an antisaccade task, to evaluate electrophysiological correlates of oculomotor control. They will use resting state functional MRI to evaluate changes to functional connectivity between nodes of brain networks involved in visual attention and oculomotor control.
OBJECTIVES:
- To measure changes in electrophysiological event-related spectral perturbation (ERSPs) associated with topdown control of saccadic eye movements during an "antisaccade" task after participants have undertaken two weeks of RECOGNeyes training.
- To measure changes in resting state connectivity between brain regions involved in visual attention and oculomotor control.
- To correlate these neural changes with training gains (measured as improvements in antisaccade task performance) and with time spent training. Associations between neural changes and improved performance will indicate that improvements in oculomotor control are reflected in alterations to underlying neural function, while associations between time spent training, training gains, and neural changes will indicate that these changes are likely to reflect RECOGNeyes training effects.
- To explore the user experience of participating in the training and identify facilitators and barriers to using RECOGNeyes as a tool for gaze-control training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
All researchers involved in data collection are masked until after data collection and preprocessing is complete.
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age range 18-30 years
- •Ability to give informed consent
- •We will prioritise recruiting volunteers who have ADHD, dyslexia, dyspraxia or dyscalculia
- •Normal or corrected-to-normal vision
排除标准
- •Magnetic Resonance Imaging safety exclusions
- •Partial sight or visual field deficit
结局指标
主要结局
Change in strength of alpha-beta oscillatory coupling
时间窗: From enrolment day visit to second visit following two weeks gaze-control training.
Change in strength of coupling between beta amplitude in right dorsolateral prefrontal cortex and high alpha amplitude in frontal eyefields during the cue-target period on anti-saccade trials, relative to prosaccade trials.
Change in beta-band oscillatory amplitude in dorsolateral pre-frontal cortex
时间窗: From enrolment day visit to second visit following two weeks gaze-control training.
Changes in beta-band (13-30 Hz) ERSP during the cue-target period of anti-saccade trials, relative to prosaccade trials.
Changes in alpha-band oscillatory amplitude in frontal eyefields
时间窗: From enrolment day visit to second visit following two weeks gaze-control training.
Changes in alpha-band (8-12 hz) ERSP during the cue-target period on anti-saccade trials, relative to prosaccade trials.
次要结局
- Changes in degree of post-stimulus beta desynchronisation and synchronisation(From enrolment day visit to second visit following two weeks gaze-control training.)
- Changes in antisaccade task performance(From enrolment day visit to second visit following two weeks gaze-control training.)
- Changes in event-related pupil dilation and vergence rates(From enrolment day visit to second visit following two weeks gaze-control training.)
- Changes in tonic pupil diameter and vergence(From enrolment day visit to second visit following two weeks gaze-control training.)
- Changes in single word reading efficiency(From enrolment day visit to second visit following two weeks gaze-control training.)
研究者
Elizabeth Liddle
Associate Professor in Translational Mental Health
University of Nottingham