Cardiac Functions in Living Donor Liver Transplant Recipients. An Echocardiographic Study.

• Conditions: Liver Transplant

• Registration Number: NCT01840514
• Lead Sponsor: Mansoura University

Brief Summary

The stress of orthotopic living donor liver transplantation in patients with cirrhosis could induce worsening of an already recorded myocardial dysfunction or may be associated with a new myocardial dysfunction in patients previously having normal myocardial functions, therefore this study will be designed for intra-operative detection of new onset ventricular dysfunction or worsening of already diagnosed ventricular dysfunction in living donor liver transplant recipient and the possible contribution of several hemodynamic and oxygenation parameters in the generation of any cardiovascular function impairment will be also investigated and to determine the impact of ventricular dysfunction on early (7 PO days) graft function, 28 days survival and patient outcomes.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-12
• Study First Submitted: 2013-04-23
• Study First Submitted QC: 2013-04-24
• Study First Posted: 2013-04-25
• Status Verified: 2013-10
• Last Update Submitted: 2013-10-04
• Last Update Posted: 2013-10-08
• Primary Completion: 2015-04
• Study Completion: 2015-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• all adult recipient

Exclusion Criteria

• massive blood transfusion
• grade III esophageal varices

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
hemodynamic monitoring	intraoperative

Secondary Outcome Measures

Name	Time	Method
graft function	7 days

Trial Locations

Locations (2)

Liver transplantation project - Gastroenterology surgical center - Mansoura university; 🇪🇬 Mansoura, Dakahlia, Egypt

Liver transplantation program - Gastroenterology surgical center; 🇪🇬 Mansoura, Dakahlia, Egypt