Epileptic Seizures in Intensive Care Units

Completed

• Conditions: Epileptic Seizure

• Registration Number: NCT03860467
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

This retrospective observational cohort study is to assess and analyze clinical, electroencephalographic, laboratory, comorbidity, and treatment characteristics of Intensive care unit (ICU)-patients with epileptic seizures and to subsequently compare their characteristics with ICU-patients with status epilepticus (SE).

Detailed Description

The aim of this retrospective observational cohort study is to get further insight into adult patients with epileptic seizures in ICUs in an academic tertiary medical care center regarding frequency, clinical and electroencephalogram (EEG) characteristics, treatment, course and outcome. This data could help understanding the epidemiology (including risk factors, influence of EEG), and to guide management and improve outcomes of affected patients.

Study Timeline

• Study First Submitted: 2019-02-26
• Study First Submitted QC: 2019-02-27
• Study First Posted: 2019-03-04
• Study Start: 2019-12-01
• Primary Completion: 2022-04-30
• Study Completion: 2022-04-30
• Status Verified: 2022-06
• Last Update Submitted: 2022-06-01
• Last Update Posted: 2022-06-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• admitted to the ICU at the University Hospital Basel
• suffered from one or more epileptic seizures (detected clinically and/or by EEG) during their ICU-stay

Exclusion Criteria

• patients with epileptic seizures transforming into Status epilepticus (SE)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency of epileptic seizures	between 01.01.2005 and 19.12.2018	Frequency of all epileptic seizures in the ICU

Secondary Outcome Measures

Name	Time	Method
Semiological feature of epileptic seizure (i.e. seizure types)	between 01.01.2005 and 19.12.2018	Semiological feature of epileptic seizure (i.e. seizure types) emerging in ICU-patients
Number of epileptic seizures captured by EEG	between 01.01.2005 and 19.12.2018	Number of epileptic seizures captured by EEG without overt clinical seizure presentation in the ICU
Number of epileptic seizures diagnosed on the basis of clinical symptoms alone	between 01.01.2005 and 19.12.2018	Number of epileptic seizures diagnosed on the basis of clinical symptoms alone in the ICU
Length of epileptic seizure (time)	between 01.01.2005 and 19.12.2018	Duration of epileptic seizure

Trial Locations

Locations (1)

Clinic for Intensive Care Medicine, University Hospital Basel; 🇨🇭 Basel, Switzerland