Prasugrel Or Ticagrelor In ST-Elevation Myocardial Infarction Patients With Diabetes Mellitus
Overview
- Phase
- Phase 3
- Status
- Completed
- Sponsor
- Gennaro Sardella
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- the superiority antiplatelet effect in terms of PR level of loading dose (LD) of Prasugrel (60 mg) versus LD of Ticagrelor (180 mg) in diabetic patients with STEMI undergoing primary PCI at 2 hours post drug administration.
Overview
Brief Summary
Dual antiplatelet therapy is essential in patients following ST-Elevation myocardial infarction (STEMI) with percutaneous coronary intervention (PCI) and drug eluting stent implantation. Current guidelines recommend prasugrel and ticagrelor in patients with STEMI undergoing primary PPCI. We sought to investigate the superiority antiplatelet effect in terms of PR level of loading dose (LD) of Prasugrel (60 mg) versus LD of Ticagrelor (180 mg) in diabetic patients with STEMI undergoing primary PCI at 1 and 2 hours post drug administration. Secondary end-points will be: PR level measured at 6 and 12 hours post study drugs administrationin hospital. All consecutive diabetic patients with STEMI undergoing PPCI with stent implantation will be considered for PR assessment at 1-2-6-12 h after the drug LD administration. All patients must will be naïve for platelet P2Y12 receptor inhibition therapy. A subanalysis will be performed between two study groups according to insulin treatment.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Diabetic patients
- •acute coronary syndrome
- •patients underwent to primary PCI
- •naïve for platelet P2Y12 receptor inhibition therapy
Exclusion Criteria
- •history of bleeding diathesis
- •chronic oral anticoagulation treatment
- •contraindications to antiplatelet therapy
- •PCI or coronary artery bypass grafting (CABG) \< 3 months
- •hemodynamic instability
- •platelet count \< 100,000/μl
- •hematocrit \< 30%
- •creatinine clearance \< 25 ml/min
- •Patients with a history of stroke
- •contraindication for prasugrel administration
Arms & Interventions
Prasugrel loading dose
Patients will be randomized to this arm to receive loading dose of prasugrel
Intervention: ticagrelor (Drug)
Prasugrel loading dose
Patients will be randomized to this arm to receive loading dose of prasugrel
Intervention: prasugrel (Drug)
Outcomes
Primary Outcomes
the superiority antiplatelet effect in terms of PR level of loading dose (LD) of Prasugrel (60 mg) versus LD of Ticagrelor (180 mg) in diabetic patients with STEMI undergoing primary PCI at 2 hours post drug administration.
Time Frame: 1 and 2 hours
Secondary Outcomes
- PR level measured at 6 and 12 hours post study drugs administration.(in hospital)
Investigators
Gennaro Sardella
Associate Professor in Cardiology
University of Roma La Sapienza