Accuracy of Intraocular Lens Power in High Myopia

• Conditions: High Myopia

• Registration Number: NCT03394300
• Lead Sponsor: Assiut University

Brief Summary

evaluation of the accuracy of iol power in high myopia using different biometry formula \& iol master

Detailed Description

High myopia or pathological myopia is associated with elongation of axial length longer than 26 mm or refractive error at least-6 diopter.

High myopia is one of the most prevalent refractive condition globally with a higher risk of other eye conditions Moreover in high myopic eyes the incidence of cataract is significantly higher than in non myopic eyes and the progression is also faster.

Calculation of IOL in high myopic eyes remains a challenge often leading to unexpected postoperative hyperopia the main potential sources of errors in IOL calculation for high myopic eyes include AL measurement \& IOL constants used \&IOL power calculation formula used.

investigators suspect that the SRK I1 formula is inaccurate for myopic eyes, and that new formulas are needed, taking into account all those factors that make up the dioptric power of an eye.

Formulas for IOL power calculation had past four generations, first generation formulas were theoretical and based on the same fundamental constant with no respect to anterior chamber depth. Since then, Binkhorst, Holladay, Hoffer and Shammas had refined the existing theoretical formulas where each of them developed his regression formula based on analysis of their previous IOL cases .

This work was amalgamated in 1980 and yielded the Sanders Retzlaff Kraff I (SRKI) formula The second generation was designed by combining linear regression analysis and stepwise adjustment for long and short eyes according to anterior chamber depth .

The third and fourth generation formulas, started by Holladay in 1988, all aimed at better calculation of the IOL power in eyes with extreme axial length where another term had appeared which is IOL specific anterior chamber depth .

The accuracy of third and fourth generation formulas for IOL calculation in patients with high axial myopia had not been fully evaluated For that, the need for more studies conducted to evaluate such accuracy is crucial.

This study will be conducted to evaluate the accuracy of different formulas used for IOL power calculation in patients with high axial myopia undergoing cataract surgery

Study Timeline

• Study First Submitted: 2017-12-29
• Status Verified: 2018-01
• Study First Submitted QC: 2018-01-07
• Last Update Submitted: 2018-01-07
• Study First Posted: 2018-01-09
• Last Update Posted: 2018-01-09
• Study Start: 2018-02-01
• Primary Completion: 2019-02-01
• Study Completion: 2019-02-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 1- patients with clear lense extraction or cataract & high myope with{ AL more than 26 mm.

2-their IOLpower is less than 15 diopter or their refraction before operation is more than -6.

Exclusion Criteria

1. Keratoconus patients or those with irregular cornea
2. Patients with post operative complications like posterior capsule injury or vitrous loss.
3. patients who had undergone previous intraocular surgery at anterior segment or posterior segment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
accuracy of iol power in high myopia	one year	biometry assment of IOLpower