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Clinical Trials/CTRI/2025/10/096296
CTRI/2025/10/096296
Not yet recruiting
Phase 4

A comparative evaluation of ultrasound guided anterior quadratus lumborum block with posterior quadratus lumborum block for total laparoscopic hysterectomy.

ASIAN INSTITUTE OF MEDICAL SCIENCES1 site in 1 country56 target enrollmentStarted: November 10, 2025Last updated:

Overview

Phase
Phase 4
Status
Not yet recruiting
Enrollment
56
Locations
1
Primary Endpoint
To compare the time to first rescue analgesic requirement after anterior versus posterior quadratus lumborum block in patients undergoing total laparoscopic hysterectomy.

Overview

Brief Summary

This prospective, randomized, double-blind, controlled clinical trial aims to compare the analgesic efficacy of two ultrasound-guided approaches of the quadratus lumborum block (QLB)—anterior  and posterior—in patients undergoing total laparoscopic hysterectomy (TLH) under general anaesthesia.

A total of 56 female patients (ASA I–II, aged 40–65 years) scheduled for elective TLH will be randomly assigned into two equal groups. Group A will receive ultrasound-guided anterior QL block, while Group B will receive posterior QL block, both using 25 mL of 0.3% ropivacaine bilaterally with 8 mg dexamethasone.

Blocks will be performed post-induction by experienced anaesthesiologists. The primary outcome is the time to first rescue analgesic requirement . Secondary outcomes include total opioid consumption within 24 hours, VAS pain scores, postoperative nausea/vomiting, sedation, and patient satisfaction scores.

The study seeks to determine whether anterior QLB provides superior postoperative analgesia and greater patient satisfaction compared to the posterior approach, potentially supporting its routine use for enhanced recovery after total laparoscopic hysterectomy.

Study Design

Study Type
Interventional
Allocation
Randomized
Masking
Participant, Investigator and Outcome Assessor Blinded

Eligibility Criteria

Ages
40.00 Year(s) to 65.00 Year(s) (—)
Sex
Female

Inclusion Criteria

  • Female patients aged 40–65 years, belonging to ASA physical status I–II, undergoing elective total laparoscopic hysterectomy under general anaesthesia will be included for this trial.

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

To compare the time to first rescue analgesic requirement after anterior versus posterior quadratus lumborum block in patients undergoing total laparoscopic hysterectomy.

Time Frame: 0-24 hours

Secondary Outcomes

  • To compare total opioid consumption within 24 hours postoperatively.

Investigators

Sponsor Class
Research institution and hospital
Responsible Party
Principal Investigator
Principal Investigator

DIVESH ARORA

Asian Hospital Faridabad

Study Sites (1)

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