Collection of Biospecimen and Analysis of the Progression of different Subtypes of Aortic Stenosis

Recruiting

• Conditions: I35.0; I50.1; Aortic (valve) stenosis; Left ventricular failure

• Registration Number: DRKS00024479
• Lead Sponsor: Herzzentrum, Klinik für Kardiologie und Pneumologie, Universitätsmedizin Göttingen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-12-10
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 453

Inclusion Criteria

Severe aortic stenosis or regurgitation that is scheduled for replacement therapy
- Informed consent

Exclusion Criteria

- Severe coagulopathy
- Documented left-ventricular thrombus
- Missing informed consent
- Non-compliant patients
- Supervised patients

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary aim of this study is to improve the understandning of molecular mechanisms underlying the development and progression of severe aortic stenosis.

Secondary Outcome Measures

Name	Time	Method
Knowledge of mechanisms underlying the development and progression of severe aortic stenosis will yield improved understanding of mechanisms leading to heart failure.