The Yorkshire Lung Screening Trial

Not Applicable

• Conditions: ung cancer; Cancer; Cancer/ Malignant neoplasms of respiratory and intrathoracic organs

• Registration Number: ISRCTN42704678
• Lead Sponsor: niversity of Leeds

Brief Summary

2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32912947/ (added 15/09/2020) 2023 Interim results article in https://pubmed.ncbi.nlm.nih.gov/37612098/ (added 25/08/2023) 2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/38986555/ Protocol for a nested randomised controlled trial (added 11/07/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2018-04-03
• Last Update Posted: 29 July 2024
• Study Completion: 2025-11-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 6892

Inclusion Criteria

The inclusion criteria for entry into the randomisation cohort are:
1. Registered with a participating General Practice within the Leeds CCG area
2. Registered as current or ex-smoker in primary care databases
3. Age between 55 and 80 years (inclusive) at the time of randomisation

The inclusion criteria for being invited to attend a mobile lung health check following contacting the telephone triage service are any of:
1. 30 pack year history of smoking and current smoker, and quit within the last 15 years, (USPSTF criteria)
2. Lung cancer risk of =1.51% over 6 years as calculated by the PLCOM2012 score
3. Lung cancer risk of =5% over 5 years as calculated by the LLPv2. score

Exclusion Criteria

1. Unable to provide written informed consent
2. Diagnosed with lung cancer within past 5 years
3. Diagnosed with incurable cancer
4. CT thorax within past 12 months
5. Registered on any of the following primary care databases:
5.1. Palliative care register
5.2. Dementia register
5.3. Frailty index > (to be decided)
6. Recorded type 2 objection to participation in the General Practice Extraction Service

Study & Design

• Study Type: Interventional
• Study Design: Not specified