A randomised controlled trial to evaluate invitation to community-based low dose computed tomography (LDCT) screening for lung cancer versus usual care in a targeted population at risk

niversity of Leeds0 sites6,892 target enrollmentApril 3, 2018

Overview

2020 Protocol article in https://pubmed.ncbi.nlm.nih.gov/32912947/ (added 15/09/2020) 2023 Interim results article in https://pubmed.ncbi.nlm.nih.gov/37612098/ (added 25/08/2023) 2024 Protocol article in https://pubmed.ncbi.nlm.nih.gov/38986555/ Protocol for a nested randomised controlled trial (added 11/07/2024)

Registry

who.int

Start Date

April 3, 2018

End Date

November 30, 2025

Last Updated

last year

Study Type

Interventional

Sex

All

Sponsor

niversity of Leeds

•The inclusion criteria for entry into the randomisation cohort are:
•1\. Registered with a participating General Practice within the Leeds CCG area
•2\. Registered as current or ex\-smoker in primary care databases
•3\. Age between 55 and 80 years (inclusive) at the time of randomisation
•The inclusion criteria for being invited to attend a mobile lung health check following contacting the telephone triage service are any of:
•1\. 30 pack year history of smoking and current smoker, and quit within the last 15 years, (USPSTF criteria)
•2\. Lung cancer risk of \=1\.51% over 6 years as calculated by the PLCOM2012 score
•3\. Lung cancer risk of \=5% over 5 years as calculated by the LLPv2\. score

•1\. Unable to provide written informed consent
•2\. Diagnosed with lung cancer within past 5 years
•3\. Diagnosed with incurable cancer
•4\. CT thorax within past 12 months
•5\. Registered on any of the following primary care databases:
•5\.1\. Palliative care register
•5\.2\. Dementia register
•5\.3\. Frailty index \> (to be decided)
•6\. Recorded type 2 objection to participation in the General Practice Extraction Service