Blended Vegetable and Fruit Juice Containing Lactobacillus paracasei Lowers Blood Lipid Levels and Oxidative Stress Markers in Thai Dyslipidemia Subjects: A Randomised Controlled Trial
- Conditions
- dyslipidemia (high level of low-density lipoprotein cholesterol (LDL-C) in the range of 130-160 mg/dL)Clinical trial, Dyslipidemia, Lactobacillus paracasei, Probiotic, Vegetable and fruit juice
- Registration Number
- TCTR20220109001
- Lead Sponsor
- Bhumibol Adulyadej Hospital
- Brief Summary
The results showed that the levels of TC, LDL-C, TG, and TG/ HDL-C ratio of the probiotic group (consumption of VFJ with L. paracasei) was significantly decreased compare to the placebo group (consumption of VFJ without L. paracasei). Whereas the HDL-C concentration in the probiotic group was higher than the placebo group. The consumption of VFJ with L. paracasei significantly decreased MDA level, increased CAT activity, and GPx activity in plasma, including increased BA level in feces of participants.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
1.The subjects were required to be aged at least 18 years., 2. The subjects had a high level of low- density lipoprotein cholesterol (LDL-C) in the range of 130-160 mg/dL according to the National Cholesterol Education Program (NCEP)., 3. The subjects never received medical treatment for dyslipidemia.
1.Having family history of dyslipidemia, 2.Having gastrointestinal surgery, 3. Suffering from metabolic disorders, cardiovascular disease, thyroid disorder, kidney disease, and liver disease, 4. Having been treated with prebiotic and/or probiotic and/or nutrition supplements, 5. Taking other drugs which possibility affect the lipid metabolism, 6.Smoking and drinking alcohol during the clinical trial.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method lipid profile and bile acid at 30 days after end of the intervention TC (mg/dL) LDL-C (mg/dL) HDL-C (mg/dL) TG (mg/dL) and BA (micromole/L)
- Secondary Outcome Measures
Name Time Method Oxidative stress enzymes at 30 days after end of the intervention CAT (unit/mL) GPx (unit/mL) SOD (unit/mL)