Therapeutic Thoracentesis for Patients With Congestive Heart Failure and Large Pleural Effusion

Not Applicable

Completed

• Conditions: Congestive Heart Failure; Transudative Pleural Effusion

• Registration Number: NCT00629538
• Lead Sponsor: Taipei Medical University Hospital

Brief Summary

Transudative pleural effusions are a common manifestation of patients with congestive heart failure. Severe dyspnea and respiratory failure may develop in those with large effusions, which in general show poor response to medical treatment. Therapeutic thoracenteses (TT) may be indicated in these patients and can produce marked relief of symptoms. However, the underlying effect of TT on gas exchange and respiratory mechanics in theses patients remains unclear. The researchers' hypothesis is that,TT may improve arterial oxygenation and respiratory mechanics in patients with congestive heart failure complicated by large pleural effusions.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-03
• Study First Submitted: 2008-02-25
• Study First Submitted QC: 2008-02-25
• Study First Posted: 2008-03-06
• Primary Completion: 2009-07
• Study Completion: 2009-07
• Status Verified: 2010-12
• Last Update Submitted: 2010-12-28
• Last Update Posted: 2010-12-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• transudative pleural effusion established by the criteria of Light
• the effusion occupying at least half of one hemithorax shown on chest radiography
• symptoms of respiratory distress
• diagnosis of congestive heart failure

Exclusion Criteria

• severe uncontrolled coagulopathy
• unstable hemodynamics
• diagnosis of liver cirrhosis, chronic obstructive pulmonary disease,asthma and/or any parenchymal lung disease, such as pneumonia, fibrosis or malignancy.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Vital signs, minute volume, expiratory tidal volume, dynamic compliance, arterial oxygen saturation and arterial blood gases, the volume of pleural fluid removed, and the changes in pleural liquid pressure and pleural space elastance	15 minutes after therapeutic thoracentesis

Trial Locations

Locations (1)

Taipei Medical University Hospital; 🇨🇳 Taipei, Taiwan