Helium 4 Optically Pumped Magnetometers : a New Generation of Sensors for High Speed Functional Brain Imaging
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Signal to Noise Ratio of the recorded brain activities
Study Overview
Brief Summary
Our goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography sensors (OPM He4) to record brain magnetic activities. The investigator will record 1) normal subjects stimulated with visual, auditory, somesthesic and motor stimuli and 2) epileptic patient. The investigator will compare the signal to noise ratio of the normal or pathological activities between classical MEG sensors and our OPM He4 prototype.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Volunteers:
- •Right handed
- •Medical insurance
- •Strongly motivated to participate to the study
- •Signed informed consent for the study
- •No previous neurology or psychiatric pathologies
- •No major cognitive deficit and able to understand the instructions
- •Right handed
- •Medical insurance
- •Strongly motivated to participate to the study
- •Signed informed consent for the study
- •No previous neurology or psychiatric pathologies (except epilepsy)
- •Epilepsy evolving during at least two years
- •No major cognitive deficit and able to understand the instructions
Exclusion Criteria
- •Volunteers:
- •Age < 18 years or > 60
- •previous neurology or psychiatric pathologies
- •Child bearing women
- •Subject having one of the following mettalic parts :
- •(pacemaker, implentable pump, neurosimulator, chochlear implant, auditory prothesis, mettalic prothesis, intracerebral clip, implantable defibrilator, any mettalic parts in the brain or upper part of the body, ventriculoperitoneal valve)
- •Claustrophobia Woman with a positive pregnancy test during the inclusion.
- •Age < 18 years or > 60
- •previous neurology or psychiatric pathologies except epilepsy
- •Child bearing women
- •Subject having one of the following mettalic parts :
- •(pacemaker, implentable pump, neurosimulator, chochlear implant, auditory prothesis, mettalic prothesis, intracerebral clip, implantable defibrilator, any mettalic parts in the brain or upper part of the body, ventriculoperitoneal valve)
- •Claustrophobia Woman with a positive pregnancy test during the inclusion.
Arms & Interventions
Sensors
All subjects will follow the same experimental procedure: a recording using classical MEG followed by a recording in the same condition with the OPM He4 prototype.
Intervention: MEG recordings (Device)
Outcomes
Primary Outcomes
Signal to Noise Ratio of the recorded brain activities
Time Frame: 1 month
Volunteers: The signal to noise ratio of normal brain activity following a stimulus will be computed with respect to the pre-stimulus baseline -100ms to -10 ms. Epileptic patient: The signal to noise ratio of abnormal epileptic brain activity will be computed with respect to a 100 ms baseline not containing any abnormal activity.
Secondary Outcomes
- Signal to Noise Ratio of pre-frontal auditory activity(one month)
- Signal to Noise Ratio of high frequency epileptic activity(one month.)
- Comfort of the subject during the MPO He4 recordings for epileptic patient through a short verbal questionary(5 minutes after the end the recording session)
- Comfort of the subject during the MPO He4 recordings for volunteers through a short verbal questionary(5 minutes after the end of each recording session)