Diagnosing exercise induced laryngeal obstruction: The influence of air temperature and humidity on exercise induced laryngeal obstruction (EILO)

Conditions: paradoxal vocal fold motion disorder
vocal cord dysfunction
10046304

Registration Number: NL-OMON51128

Lead Sponsor: Medisch Spectrum Twente

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 31

Inclusion Criteria

-Age 10 to 24 years
-Clinical suspicion of EILO and planned for ECT
-Ability to perform exercise challenge test on treadmill or bike
-Written informed consent of patient and/or parents or legal guardians

Exclusion Criteria

-Other severe cardiopulmonary disease
-Baseline FEV1 <70 % of predicted
-Use of long acting bronchodilator agents 24 hours before testing
-Use of short acting bronchodilator agents 8 hours before testing

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters/endpoints: The main study parameter is the difference of<br /><br>occurrence of EILO (defined as Maat sumscore >2) during CLE testing at room<br /><br>temperature and in cold, dry air. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-EILO grade score (Maat score; glottic or supraglottic, grade 1-3)<br /><br>-Symptoms reported<br /><br>-Duration until start of symptoms after start of exercise, and duration until<br /><br>peak dyspnoea<br /><br>-VAS score: before exercise, at peak level of dyspnoea and 2 minutes after<br /><br>exercise<br /><br>-Physiologic measurements: breathing frequency, heart rate, heart rate recovery<br /><br>time, blood pressure<br /><br>-EMG measurements of diaphragm before and after exercise<br /><br>-Respiratory induction plethysmography (RIP) during exercise<br /><br>-Lung function with in- and expiratory flow volume loops before and at 1, 3, 6<br /><br>minutes after exercise<br /><br>-FOT measurements before and after exercise<br /><br>-Audio-visual recordings: breath sounds, observed breathing pattern<br /><br>-Max Wattage/kg or maximum running pace<br /><br>-Questionnaire about perceived symptoms and influence of environmental factors<br /><br>-Astma control test</p><br>