Colorectal Cancer Control in Low Resource Countries: Results From a Prospective Cohort Study of Patients at High-risk for Colorectal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To determine colonoscopy polyp and cancer detection rate
研究概览
简要总结
Patient age 45 year old and above who presented with rectal bleeding at three tertiary hospitals in South West Nigeria were invited for colonoscopy. The clinical information of the patients and the colonoscopy data were analyzed
详细描述
Patient age 45 year old and above who presented with rectal bleeding at Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Nigeria, University College Hospital, Ibadan, Nigeria, and University of Ilorin Teaching Hospital, Ilorin Nigeria were invited for colonoscopy. Categorical variables were compared using χ2-test or Fisher's exact test while the Kruskal-Wallis test was used for quantitative variables. Multivariate analysis was performed using logistic regression model. All statistical tests were two-sided and p-values below 0.05 were considered statistically significant. Statistical analysis was carried out using SAS 9.4 and R 3.3.1.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •must be 45-years of age or older
- •has rectal bleeding lasting at least one week
- •has had a complete colonoscopy performed
排除标准
- •Individuals with a personal history of inflammatory bowel disease, colorectal polyps, colorectal adenoma or CRC
- •Individuals with a family history of familial adenomatous polyposis syndromes or other hereditary polyposis syndromes, hereditary nonpolyposis colorectal cancer
- •Individuals with severe comorbidities that were contraindication to colonoscopy
- •Individuals who had a previous history of colectomy
结局指标
主要结局
To determine colonoscopy polyp and cancer detection rate
时间窗: 2 years
The hypothesis for this study was that colonoscopy surveillance of a high-risk cohort of patients with rectal bleeding would demonstrate that 10-20% of these patients have pre-malignant colorectal polyps(adenomas) or cancers.
次要结局
- To detect colorectal cancer early using symptoms based assessment(2 years)
研究者
Olusegun Alatise
Consultant Surgeon/Senior Lecturer
Obafemi Awolowo University Teaching Hospital