Mamma Board Project: Prone Breast Irradiation for Pendulous Breasts
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Dose Homogeneity 1: PTV
研究概览
简要总结
We hypothesize that for large pendulous breasts, breast irradiation in supine and prone position are equivalent with regard to coverage of the PTV, but with a better dose homogeneity in prone position and a smaller radiation exposure of lung and heart.The purpose of this study is to compare the 3-D dose distribution in PTV(Planning Target Volume) and normal tissues in prone position versus supine position.
详细描述
Local excision followed by adjuvant radiotherapy has become standard treatment for women with early-stage breast cancer. Adjuvant radiotherapy may encounter technical difficulties in patients with pendulous breasts when treated in supine position.
Based upon literature and our own preliminary experiences, we hypothesize that for large pendulous breasts, breast irradiation in supine and prone position are equivalent with regard to coverage of the PTV, but with a better dose homogeneity in prone position and a smaller radiation exposure of lung and heart. However, no quantitative data are yet available to test this hypothesis. Therefore, the aim of our study is to compare the 3-D dose distribution in PTV and normal tissues in prone position versus supine position. For treatment in prone-position an in-house developed device, the "mammaboard" was used.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients should have had breast-conserving surgery for breast cancer or DCIS (Ductal Carcinoma in Situ)
- •No indication for radiotherapy of regional nodes
- •Large, pendulous breasts (bra size D and over)
排除标准
- •Regional radiotherapy is indicated
- •Unable to lie in prone position
结局指标
主要结局
Dose Homogeneity 1: PTV
时间窗: 1 day after treatment planning
Quantitatively compare the 3 D dose distribution in the PTV (Planning Target Volume) and normal tissues in prone position versus supine position
Dose Homogeneity 3: V95 %
时间窗: 1 day after treatment planning
PTV coverage (% of PTV \< 95% of prescribed dose) in prone position versus supine position
Dose Homogeneity 2: V105% and V107%
时间窗: 1 day after treatment planning
Quantitatively compare the 3 D dose distribution in the PTV (Planning Target Volume) in prone position versus supine position
次要结局
- PTV Coverage in Organs at Risk: Heart V30(during treatment planning)
- PTV Coverage in Organs at Risk: MLD (Gy)(during treatment planning)
