Sustained effects of resveratrol on circulatory function in obese adults

Not Applicable

Completed

• Conditions: Endothelial vasodilator function; Cognitive function; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12611000060943
• Lead Sponsor: Professor Peter Howe

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-01-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Men or post-menopausal women (self reported cessation of menses for at least 12 months)
Age: 40-70 years.
Obese (BMI 30-45 kg/m2) but otherwise healthy

Exclusion Criteria

- Supine BP above SBP 160 mmHg or DBP 100 mmHg
- Having cardiovascular disease, renal disease or diabetes
- Taking BP lowering medication
- Having any other medical condition or treatments (including supplements) which, in the opinion of the investigators, may influence the outcome of the study
- Smokers or those using nicotine replacement therapy
- Those unwilling to restrict food items containing high amounts of polyphenols (grape, grape juice, wine, peanuts, peanut butter, mulberries, green tea, soy and soy products)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Degree of change in vasodilator function assessed by flow mediated dilatation in the brachial artery.[There will be 5 assessments at three time points. Baseline, week 6, then crossover to alternate dose (active or placebo), then assessment at week 12, plus an acute supplementation assessment at week 6 and 12. The acute assessments will be performed after the chronic assessments have been made on a given visit. The purpose of these measures is to determine an acute effect may be potentiated by the chronic exposure]