NL-OMON34762
Completed
Not Applicable
Modeling the respiratory effects of subanesthetic doses of propofol under closed-loop or non-steady-state conditions without and with a remifentanil background infusion in healthy volunteers. - Modeling the respiratory effects of a propofol-remifentanil interaction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ventilatie/ademhaling
- Sponsor
- eids Universitair Medisch Centrum
- Enrollment
- 24
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy volunteers of either sex in age range 18\-45 years.
Exclusion Criteria
- •Obesity (BMI \> 35\)
- •Presence of medical disease
- •Presence of psychiatric disease
- •History of chronic alcohol or illicit drug use
- •Allergy to study medications
- •Difficult to hold to subject on mask causing leakage and inability to perform mask ventilation (i.e. Mallampati classification 3 or greater)
- •For females we require use of contraceptives
Outcomes
Primary Outcomes
Not specified
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Modeling the respiratory effects of subanesthetic doses of propofol under closed-loop or non-steady-state conditions without and with a remifentanil background infusion in healthy volunteers.This study is performed in healthy volunteers. The study is aimed at investigating the effect of propofol and remifentanil-propofol interaction on breathing in awake, non-artificially ventilated volunteers under non steady state conditions.EUCTR2010-018233-21-NLeiden University Medical Centre
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