NL-OMON34762CompletedNot Applicable
Modeling the respiratory effects of subanesthetic doses of propofol under closed-loop or non-steady-state conditions without and with a remifentanil background infusion in healthy volunteers. - Modeling the respiratory effects of a propofol-remifentanil interaction
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 24
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •Healthy volunteers of either sex in age range 18-45 years.
Exclusion Criteria
- •Obesity (BMI > 35)
- •Presence of medical disease
- •Presence of psychiatric disease
- •History of chronic alcohol or illicit drug use
- •Allergy to study medications
- •Difficult to hold to subject on mask causing leakage and inability to perform mask ventilation (i.e. Mallampati classification 3 or greater)
- •For females we require use of contraceptives
Investigators
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Modeling the respiratory effects of subanesthetic doses of propofol under closed-loop or non-steady-state conditions without and with a remifentanil background infusion in healthy volunteers.This study is performed in healthy volunteers. The study is aimed at investigating the effect of propofol and remifentanil-propofol interaction on breathing in awake, non-artificially ventilated volunteers under non steady state conditions.EUCTR2010-018233-21-NLeiden University Medical Centre
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