The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk

Not Applicable

Completed

• Conditions: Diabetes; Prediabetes
• Interventions: Dietary Supplement: Oral fat tolerance test

• Registration Number: NCT01972542
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

The hypertriglyceridemia at fasting status has been known to be an important risk factor for cardiovascular disease (CVD). Recently, postprandial triglyceride (TG) levels draw an attention as a superior predictor of CVD because of non-fasting state for more than 12 hours and importance of triglyceride-rich lipoprotein.

We aim to investigate the relationship of postprandial triglyceride after fat tolerance test and intima-medial thickness and to suggest normal reference of postprandial triglyceride after fat tolerance test. In addition, we evaluate the correlation of postprandial triglyceride and incretin secretion after fat tolerance test Ultimately, we want to estimate clinical importance of postprandial triglyceride in assessment of cardiovascular risk.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2013-10-23
• Study First Submitted QC: 2013-10-24
• Study First Posted: 2013-10-30
• Primary Completion: 2015-07
• Study Completion: 2015-08
• Status Verified: 2015-10
• Last Update Submitted: 2015-10-23
• Last Update Posted: 2015-10-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• age : 19 ~ 70 yrs
• Type 2 diabetes : HbA1c <10%
• Prediabetic state : HbA1c 5.7~6.4%

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Exclusion Criteria

• Type 1 diabetes, secondary diabetes
• dipeptidyl peptidase-4 -inhibitor, glucagon-like peptide-1 agonist, thiazolidinediones users
• Thyroid disease with abnormal thyroid function test
• Liver disease with abnormal liver function test
• severe kidney disease
• pregnant or lactating women
• current smoker
• severe obesity

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Prediabetes	Oral fat tolerance test	Intervention : Oral fat tolerance test Glucose 140-199 mg/dL after 75g oral glucose tolerance test HbA1c 5.7-6.4%
Type 2 DM	Oral fat tolerance test	Intervention : Oral fat tolerance test well or moderately controlled type 2 diabetes mellitus (HbA1c \< 10%) No dipeptidyl peptidase-4 -inhibitor, Glucagon-like peptide-1 agonist, thiazolidinediones
Normal glucose tolerance	Oral fat tolerance test	Intervention : Oral fat tolerance test No impaired fasting glucose and impaired glucose tolerance

Primary Outcome Measures

Name	Time	Method
Changes of Triglyceride	8 hours	Blood sample : drawn by a catheter before the meal and every 1 hour after meal over the 8-hour period

Secondary Outcome Measures

Name	Time	Method
Changes of incretin	8 hours

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Korea, Republic of