The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk in Healthy People, Impaired Glucose Tolerance and Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Changes of Triglyceride
研究概览
简要总结
The hypertriglyceridemia at fasting status has been known to be an important risk factor for cardiovascular disease (CVD). Recently, postprandial triglyceride (TG) levels draw an attention as a superior predictor of CVD because of non-fasting state for more than 12 hours and importance of triglyceride-rich lipoprotein.
We aim to investigate the relationship of postprandial triglyceride after fat tolerance test and intima-medial thickness and to suggest normal reference of postprandial triglyceride after fat tolerance test. In addition, we evaluate the correlation of postprandial triglyceride and incretin secretion after fat tolerance test Ultimately, we want to estimate clinical importance of postprandial triglyceride in assessment of cardiovascular risk.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age : 19 ~ 70 yrs
- •Type 2 diabetes : HbA1c <10%
- •Prediabetic state : HbA1c 5.7~6.4%
排除标准
- •Type 1 diabetes, secondary diabetes
- •dipeptidyl peptidase-4 -inhibitor, glucagon-like peptide-1 agonist, thiazolidinediones users
- •Thyroid disease with abnormal thyroid function test
- •Liver disease with abnormal liver function test
- •severe kidney disease
- •pregnant or lactating women
- •current smoker
- •severe obesity
结局指标
主要结局
Changes of Triglyceride
时间窗: 8 hours
Blood sample : drawn by a catheter before the meal and every 1 hour after meal over the 8-hour period
次要结局
- Changes of incretin(8 hours)
研究者
Soo Lim
Professor
Seoul National University Bundang Hospital