Circulating microRNAs as Biomarkers of Sepsis
Completed
- Conditions
- Sepsis
- Registration Number
- NCT00862290
- Lead Sponsor
- Changhai Hospital
- Brief Summary
MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- patients who develop sepsis and undergo abdominal surgery
- patients who develop SIRS after cardiac surgery with cardiopulmonary bypass
Exclusion Criteria
- patients with a primary diagnosis of acute pancreatitis
- patients with cirrhosis or renal dysfunction
- patients with dyscrasia
- patients with autoimmunity diseases
- patients with severe cardiac and pulmonary diseases
- patients with hematological diseases
- patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Relative amount of circulating microRNAs On the second day of diagnosis of sepsis in ICU
- Secondary Outcome Measures
Name Time Method Serum levels of CRP and IL-6 On the second day of diagnosing sepsis Apache II score and death On the second day of diagnosis of sepsis
Trial Locations
- Locations (1)
Changhai Hospital, Second Military Medical University
🇨🇳Shanghai, China