Diagnostic and Predictive Value of Circulating microRNAs During Sepsis

Changhai Hospital1 site in 1 country100 target enrollmentAugust 2008

ConditionsSepsis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Sepsis
Sponsor: Changhai Hospital
Enrollment: 100
Locations: 1
Primary Endpoint: Relative amount of circulating microRNAs
Status: Completed
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.

Registry

clinicaltrials.gov

Start Date

August 2008

End Date

June 2009

Last Updated

13 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Changhai Hospital

Responsible Party

Principal Investigator

Jia-feng Wang

M.D.

Changhai Hospital

Eligibility Criteria

Inclusion Criteria

•patients who develop sepsis and undergo abdominal surgery
•patients who develop SIRS after cardiac surgery with cardiopulmonary bypass

Exclusion Criteria

•patients with a primary diagnosis of acute pancreatitis
•patients with cirrhosis or renal dysfunction
•patients with dyscrasia
•patients with autoimmunity diseases
•patients with severe cardiac and pulmonary diseases
•patients with hematological diseases
•patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass