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临床试验/NCT07535320
NCT07535320招募中不适用

Study of Patient Preferences in Dialysis Treatment Choice: a Discrete Choice Experiment

University Hospital, Caen2 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2025年12月16日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
500
试验地点
2
主要终点
Preference coefficients for renal replacement therapy attributes, including monthly financial allowance, estimated using a discrete choice experiment

研究概览

简要总结

Background Compared to in-center dialysis, home dialysis is associated with better quality of life and lower healthcare system costs. However, barriers remain to its wider adoption. Chronic disease, particularly at an advanced stage, is a major driver of socioeconomic vulnerability. Among dialysis patients, the proportion of individuals covered by France's Universal Health Protection scheme (PUMA) is higher than in the general population. Similarly, those from the most disadvantaged social classes are overrepresented among dialysis patients compared to the overall French population. Dialysis can also lead to job loss. Financial compensation schemes may influence the choice of home dialysis. In France, patients who perform dialysis at home-either independently or with help from a trained family caregiver-are eligible for a "third-person compensatory allowance" (DTP). For some socioeconomically vulnerable patients, eligibility for DTP may influence their decision to opt for home treatment. The DTP is specific to the French healthcare system but could be considered in other countries, particularly within the European Union. Indeed, in most countries with income levels comparable to France, the additional cost of home dialysis is borne by the patient. This study aims to determine whether receiving financial compensation plays a role in choosing a dialysis modality (home-based versus in-center or assisted home dialysis).

Objectives To investigate factors associated with patient preferences regarding renal replacement therapy.

Methods A discrete choice experiment (DCE) was conducted comparing two options: home dialysis (PD and HHD, with DTP) versus in-center hemodialysis (no DTP).

Perspectives If financial compensation influences patients' choices toward home dialysis, the DTP model could be used to address barriers to home-based treatment.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Other

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult patient
  • Patient with advanced chronic kidney disease receiving pre-surgery information (presentation of methods)
  • Patient enrolled in a social security program
  • Patient able to read and understand French
  • Patient able to complete the questionnaire (cognitive and sensory)

排除标准

  • Minor patients
  • Patients transitioning from one method of extrarenal purification to another
  • Patients requiring urgent dialysis
  • Patients who cannot read or understand French
  • Patients under legal protection (guardianship, curatorship, judicial protection)

研究组 & 干预措施

Choice of dialysis

Patients with an end-stage renal disease who need to make a choice concerning their prefered dialysis' modality

干预措施: Questionnaire (Other)

结局指标

主要结局

Preference coefficients for renal replacement therapy attributes, including monthly financial allowance, estimated using a discrete choice experiment

时间窗: Baseline (during the single discrete choice experiment assessment at study enrollment)

Participants will complete 13 discrete choice tasks, each requiring selection of one preferred scenario among three renal replacement therapy options. Scenarios are defined by combinations of five attributes: schedule flexibility, nurse availability, dialysis frequency, timing of sessions, and monthly financial allowance. Preferences will be analyzed within a random utility framework using a mixed logit model. The primary outcome is the estimation of marginal utilities (preference coefficients) associated with each attribute level. Particular focus will be placed on the coefficient associated with the monthly financial allowance attribute, to assess its influence on the probability of choosing a home-based treatment modality. This approach allows indirect elicitation of patient preferences without explicit ranking, consistent with economic theory of revealed preferences.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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