The Effect of Simulated Burn Injury on Post Exercise Recovery in a Hot Environment

Not Applicable

Not yet recruiting

• Conditions: Burn Injury

• Registration Number: NCT07050264
• Lead Sponsor: University of Texas Southwestern Medical Center

Brief Summary

Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. We have previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-06
• Study First Submitted: 2025-06-25
• Study First Submitted QC: 2025-06-25
• Last Update Submitted: 2025-06-25
• Study First Posted: 2025-07-03
• Last Update Posted: 2025-07-03
• Study Start: 2025-08-01
• Primary Completion: 2028-08-01
• Study Completion: 2028-08-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Participants will be 18 and 65 years of age and must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram.

Exclusion Criteria

• Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc.; as well as serious abnormalities detected on routine screening. Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test. Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response will likewise be an exclusion. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants will also be excluded if body mass index is ≥ 31 kg/m2.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Core Temperature	From baseline to end of 60 minutes of recovery

Secondary Outcome Measures

Name	Time	Method
Heart Rate	From baseline to the end of 60 minutes of recovery

Trial Locations

Locations (1)

Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas; 🇺🇸 Dallas, Texas, United States