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临床试验/NCT07050264
NCT07050264招募中不适用

The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments

University of Texas Southwestern Medical Center1 个研究点 分布在 1 个国家目标入组 28 人开始时间: 2026年3月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
28
试验地点
1
主要终点
Core Temperature

研究概览

简要总结

Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者
是

入选标准

  • •18 and 65 years of age
  • •free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram.

排除标准

  • •Known heart disease
  • •other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc. as well as serious abnormalities detected on routine screening.
  • •Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test.
  • •Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response.
  • •Current smokers, as well as individuals who regularly smoked within the past 3 years.
  • •body mass index is ≥ 31 kg/m2.

研究组 & 干预措施

Hot and Humid with simulated burns

Experimental

Individuals will be exposed to hot and humid conditions with a simulated burn injury.

干预措施: Simulated burn injury via application of absorbent and impermeable material over 60% of the body (Other)

Hot and Humid without simulated burns

No Intervention

Individuals will be exposed to hot and humid conditions without a simulated burn injury.

Hot and Dry with simulated burns

Experimental

Individuals will be exposed to hot and dry conditions with a simulated burn injury.

干预措施: Simulated burn injury via application of absorbent and impermeable material over 60% of the body (Other)

Hot and Dry without simulated burns

No Intervention

Individuals will be exposed to hot and dry conditions without a simulated burn injury.

结局指标

主要结局

Core Temperature

时间窗: From baseline to end of 60 minutes of recovery

次要结局

  • Heart Rate(From baseline to the end of 60 minutes of recovery)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Craig Crandall

Professor of Internal Medicine and director of the thermal and vascular physiology lab

University of Texas Southwestern Medical Center

研究点 (1)

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