Effect of Ursodeoxychoil Acid in Functional Dyspeptic Patients with Small Intestinal Bacterial Overgrowth
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0004910
- Lead Sponsor
- Ajou University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 24
The Rome IV criteria define FD as one of four symptoms (postprandial fullness, early satiation, epigastric pain, epigastric burning) that occurred at least six months before diagnosis and persisted for the last three months. In addition, examinations involving endoscopy should reveal no structural abnormalities to explain these symptoms.
Patients with FD were excluded from this study if they had a history of i) gastrointestinal ulcers or inflammatory bowel diseases such as Crohn's disease or ulcerative colitis; ii) gastrectomy or intestinal resection (except appendectomy); or iii) viral liver disease (types A, B, C), cirrhosis, or any cancers, as well as iv) blood tests whose serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) or gamma-glutamyltransferase (GGT) levels were more than three times the normal range or whose serum creatinine levels were more than 1.5 times the normal range; v) chronic renal failure, congestive heart failure, and thyroid disease; vi) persistent alcohol consumption (at least four bottles of soju per week, i.e., at least 240g of alcohol per week); or vii) severe biliary obstruction.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The questionnaire about dyspepsia measured each patient’s Nepean dyspepsia index-K (NDI-K) and Small intestinal bacterial overgrowth prevalence.
- Secondary Outcome Measures
Name Time Method Adverse events