NL-OMON55733已完成4 期
The effects of sex hormone administration on marrow and visceral adiposity - SHAMVA
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •- Diagnosed with gender dysphoria according to DSM V (transmen or
- •transwomen)
- •- Age between 18 and 50 years
- •- Transmen need to be premenopausal
- •- Starting cross-sex hormone treatment
排除标准
- •- Previous use of cross-sex hormones
- •- Use of hormonal contraceptives (exception for Mirena sipral)
- •- Contraindications to MRI scanning as determined by the standard AMC checklist
- •- Use of bone-modifying or adipose tissue-modifying drugs, current or in history
- •- Bisphosphonates (alendronic acid, clodronic acid, ibandronic acid, pamidronic
- •acid, risedronic acid, zoledronic acid, etidronate)
- •- Estrogen receptor modulators (raloxifene, bazedoxifene)
- •- Calcium regulating agents (e.g. denosumab, calcitonin, teriparatide,
- •strontium ranelate, cinacalcet, etelcalcetine)
- •- Corticosteroids
- •- Bone or bone marrow diseases, current or in history
- •- Metabolic (osteroporosis, osteomalacia, dystosis, osteodystrophia, Pagets
- •disease, osteogenesis imperfecta)
- •- Malignancy (primary, metastatic)
- •- Infectious (osteomyelitis, periostitis), Mechanic (lumbal vertebral
- •fracture), Bone marrow diseases (leukemia, myelodysplastic syndrome,
- •myeloproliferative disorders)
- •- Platelet count <120*10^9/l
- •- History of non-traumatic major bleeding
- •- Known bleeding diathesis
- •- Conditions which require antiplatelet therapy
- •- Usage of antiplatelet therapy
- •- Chronic usage of medication known to influence platelet function (e.g.
- •DOAC*s, NSAIDs, warfarin)
研究者
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