A Multicenter, Open-Label, Phase Ib/II Trial of SHR-1701 Plus BP102 in Subjects With Selected Solid Tumors

Suzhou Suncadia Biopharmaceuticals Co., Ltd.0 sites71 target enrollmentAugust 30, 2021

ConditionsAdvanced or Metastatic Non-squamous Non-small Cell Lung Cancer

InterventionsSHR-1701；BP102

DrugsSHR-1701；BP102

Overview

Phase: Phase 2
Intervention: SHR-1701；BP102
Conditions: Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer
Sponsor: Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Enrollment: 71
Primary Endpoint: Objective response rate (ORR)
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Similar Trials

Overview

Brief Summary

The main purpose of this study was to assess the safety,efficacy and pharmacokinetic when combining SHR-1701 and BP102 in participants with advanced or metastatic non-squamous non-small cell lung cancer. To explore the immunogenicity of SHR-1701 and the relationship between corresponding biomarkers and therapeutic effect.

Registry

clinicaltrials.gov

Start Date

August 30, 2021

End Date

August 30, 2022

Last Updated

4 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Histologically or cytologically confirmed advanced or metastatic non-squamous non-small cell lung cancer.
•Failed with prior systemic treatments.
•Measurable disease, as defined by RECIST v1.1
•The Eastern Cancer Cooperative Group (ECOG) performance status of 0 or 1
•Life expectancy ≥ 3 months
•Adequate hematologic and end-organ function as defined in the protocol

Exclusion Criteria

•Histologically or cytologically confirmed mixed SCLC and NSCLC.
•Symptomatic, untreated or active central nervous system metastases.
•Systemic therapy with immunosuppressive agents within 2 weeks prior to initiation of study treatment
•With any active autoimmune disease or history of autoimmune disease.
•Inadequately controlled hypertension.
•Tumor infiltration into the great vessels on imaging.
•History of hemoptysis ≥2.5ml per episode within 1 month prior to initiation of study treatment.
•Uncontrolled tumor-related pain.
•Patients with active hepatitis B or hepatitis C
•Severe infections within 4 weeks prior to initiation of study treatment.