Interaction and Modulation of Salivary Proteins With Repeat Exposure to Polyphenols
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Relative salivary proteins in saliva
研究概览
简要总结
Participants will be chosen through an initial sensory test to find high and low-perceivers of astringency. Selected participants will drink a chocolate milk or milk substitute beverage for one week each with washout weeks in between. At the end of each week participants will taste and rate multiple beverages for their astringency and other sensory properties. Participants will provide saliva samples weekly for proteomic analysis and (potentially) analysis of polyphenols. Participants will also be asked to provide a 24 hour dietary recall once per week. Data will be analyzed to determine if there is a relationship between polyphenol exposure, astringency ratings, and salivary protein composition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
Participants will not know the specifics of each beverage they are taking home.
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •High or low perceivers of astringency (from initial screening)
排除标准
- •Current smokers (within 30 days), dairy/nut/cocoa allergies, piercings in mouth, mid-range perceiver of astringency, issues with taste, smell, swallowing or choking.
研究组 & 干预措施
SBG
Participant receives milk substitute, then bovine milk, then milk substitute with gelatin.
干预措施: Chocolate milk substitute (Other)
BGS
Participant receives bovine milk, then milk substitute with gelatin, then milk substitute
干预措施: Chocolate milk substitute with gelatin (Other)
BSG
Participant receives bovine milk, then milk substitute, then milk substitute treated with gelatin
干预措施: Chocolate Milk (Other)
BSG
Participant receives bovine milk, then milk substitute, then milk substitute treated with gelatin
干预措施: Chocolate milk substitute (Other)
BSG
Participant receives bovine milk, then milk substitute, then milk substitute treated with gelatin
干预措施: Chocolate milk substitute with gelatin (Other)
BGS
Participant receives bovine milk, then milk substitute with gelatin, then milk substitute
干预措施: Chocolate Milk (Other)
BGS
Participant receives bovine milk, then milk substitute with gelatin, then milk substitute
干预措施: Chocolate milk substitute (Other)
SBG
Participant receives milk substitute, then bovine milk, then milk substitute with gelatin.
干预措施: Chocolate Milk (Other)
SBG
Participant receives milk substitute, then bovine milk, then milk substitute with gelatin.
干预措施: Chocolate milk substitute with gelatin (Other)
SGB
Participant receives milk substitute, then milk substitute with gelatin, then bovine milk
干预措施: Chocolate Milk (Other)
SGB
Participant receives milk substitute, then milk substitute with gelatin, then bovine milk
干预措施: Chocolate milk substitute (Other)
SGB
Participant receives milk substitute, then milk substitute with gelatin, then bovine milk
干预措施: Chocolate milk substitute with gelatin (Other)
GSB
Participant receives milk substitute with gelatin, then milk substitute, then bovine milk.
干预措施: Chocolate Milk (Other)
GSB
Participant receives milk substitute with gelatin, then milk substitute, then bovine milk.
干预措施: Chocolate milk substitute (Other)
GSB
Participant receives milk substitute with gelatin, then milk substitute, then bovine milk.
干预措施: Chocolate milk substitute with gelatin (Other)
GBS
Participant receives milk substitute with gelatin, then bovine milk, then milk substitute.
干预措施: Chocolate Milk (Other)
GBS
Participant receives milk substitute with gelatin, then bovine milk, then milk substitute.
干预措施: Chocolate milk substitute (Other)
GBS
Participant receives milk substitute with gelatin, then bovine milk, then milk substitute.
干预措施: Chocolate milk substitute with gelatin (Other)
结局指标
主要结局
Relative salivary proteins in saliva
时间窗: 1 year
Measure relative amounts of salivary proteins in participant saliva.
次要结局
- Chocolate milk substitute with gelatin flavor ratings(8 months)
- Chocolate milk substitute flavor ratings(8 months)
- Chocolate milk flavor ratings(8 months)
- Subject Diets(8 months)
- Polyphenol content in saliva samples(8 months)
研究者
Cordelia Running, PhD
Assistant Professor
Purdue University