Exercise-induced oxidative stress and peripheral muscle dysfunction in COPD; single-leg ergometer test versus whole-body exercise test.

Completed

• Conditions: chronic lung disease; COPD; 10028302; 10038716

• Registration Number: NL-OMON30201
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 54

Inclusion Criteria

-Diagnosis of COPD according to the American Thoracic Society (ATS) guidelines
-No respiratory tract infection or exacerbation of their disease for at least 4 weeks before the study

Exclusion Criteria

-Smokers
-Use of oxygen supplementation
-Other chronic diseases such as rheumatoid arthritis, chronic colitis and diabetes
-Cardiovascular diseases, renal diseases, liver diseases or mental diseases

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Various parameters of oxidative stress will be analyzed in blood, urine as well<br /><br>in exhaled breath. These pulmonary and systemic oxidative stress markers will<br /><br>be compared between COPD patients and healthy controls at rest and during<br /><br>exercise. Mechanical efficiency and endurance of the quadriceps femoris muscle<br /><br>in COPD versus healthy controls will be tested with the single-leg ergometer<br /><br>test. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To investigate possible determinants of quadriceps femoris muscle endurance<br /><br>(impairment of airway obstruction, exercise capacity, daily activity level, leg<br /><br>muscle strength, total body and leg FFM).</p><br>