DNA damage and Nutritional Profile of ApoE4 carriers, the Major Genetic Risk Factor for Alzheimer’s Disease

Not Applicable

Recruiting

• Conditions: Alzheimer's Disease; Neurological - Alzheimer's disease

• Registration Number: ACTRN12612000098831
• Lead Sponsor: Commonwealth Scientific and Industrial Research Organisation

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-01-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Inclusion Criteria
Aged 35-65 years; Healthy; Non-smokers; Male & Female

Exclusion Criteria

Exclusion Criteria:
Mini-mental State Examination (MMSE) score of less than 20. (short mental examination); Currently diagnosed with AD or Mild cognitive impairment; On Medication for life threatening diseases (i.e. chemotherapy); Taking mineral and vitamin supplements above the RDA level on a daily basis; Taking fish oil and antioxidant supplements investigated in the study; Unable to understand the study protocol

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determine DNA damage, micronutrient and lipid profile of ApoE4 carriers compared to non-carriers using the cytokinesis block micronucleus assay.[Only one sample collection is involved. Samples are set up fresh to determine DNA damage and lipid profile of the volunteers.]

Secondary Outcome Measures

Name	Time	Method
To determine if nutritional supplementation with lipophilic antioxidants and omega-3 fatty acids, in vitro can prevent DNA damage in ApoE4 carriers compared to non-carriers.[This is performed in the lab on lymphocytes isolated from the blood, once the DNA damage, micronutrient and lipid profiles have been established.]